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BRAIN SPECIFIC 24S HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cholesterol 24-Hydroxylase
Descriptor
Spanish
:
Colesterol 24-Hidroxilasa
Descriptor
Portuguese
:
Colesterol 24-Hidroxilase
Synonyms
English
:
5(beta)-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol-24S-hydroxylase
Brain Specific 24S Hydroxylase
Brain-Specific 24S-Hydroxylase
CYP46A1
Cholestane Tetrol 24 Hydroxylase
Cholestane Tetrol 24-Hydroxylase
Cholesterol 24 Hydroxylase
Cytochrome P450 46A1
Tree Number:
D08.244.453.875.500
D08.244.453.915.025
D08.811.682.690.708.170.497.500
D08.811.682.690.708.170.915.025
D12.776.422.220.453.875.500
D12.776.422.220.453.915.025
Definition
English
:
A steroid hydroxylase that functions in
CHOLESTEROL
homeostasis
in the brain. It converts
cholesterol
into 24S-hydroxycholesterol, which is transported over the
BLOOD-BRAIN BARRIER
more rapidly than unmetabolized
cholesterol.
History Note
English
:
2017 (1999)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56451
Unique Identifier:
D000072556
Occurrence in VHL
:
Similar:
DeCS